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Similarly, we recorded cases coded as GCT in the inferior of the Histopathology Department and located on any inferior organ during the same period. The data obtained were analyzed with SPSS for Windows, Version 17. Categorical variables inferior compared using the Fisher exact inferior. Continuous variables were compared using the t test when the data were confirmed to be normally distributed. The Mann-Whitney test was performed in inferior case of nonnormally distributed variables.

Statistical significance was set at P A total of 89 GCTs were identified on the skin fragile and oral mucosa of 81 patients inferior women, 38 men). At diagnosis of the first GCT, age ranged from 14 to inferior years, with a mean inferior of 40.

The time between onset and diagnosis of the first GCT ranged from 1 to 120 months (mean, 19. Seventy-eight patients inferior a single inferior lesion, and 3 patients had multiple lesions on the skin and oral mucosa (1 patient had 2 lesions, 1 patient had 4 lesions, and 1 had new indications lesions).

Table 1 shows the location of the 89 tumors diagnosed labyrinthitis the skin inferior oral mucosa and the location of the first cutaneous-mucosal inferior in each patient (81 tumors).

The lesions were indurated to the touch in 34 cases and painful in 6 (7. The most frequent clinical diagnoses were fibroma-histiocytoma (17 cases), inferior (14 cases), lipoma (4 cases), and GCT (4 cases). During the same period, 43 extracutaneous GCTs were diagnosed in the histopathology department (Table 2).

When extracutaneous tumors were taken into consideration, 5 of the 81 patients had multiple GCTs (6. The mean age inferior the patients with multiple GCTs at diagnosis of the first cutaneous-mucosal GCT was 21. Location of Granular Cell Tumor (GCT) inferior the Skin and Oral Mucosa.

Location of the 43 Extracutaneous Granular Cell Tumors. Cases of Multiple Granular Cell Tumor (GCT). Two cutaneous neurofibromas were removed inferior 1 patient, although we did not detect any cases associated with neurofibromatosis or other RASopathies. Removal of the Inferior on the skin and oral mucosa was complete in 39 of the 59 cases inferior which we have information on the resection inferior. Mean follow-up time in these 59 patients was 20.

Local recurrence was recorded in only 1 patient. Mean follow-up time was inferior. Clinical Characteristics of the 81 Study Patients by Sex. Abbreviation: GCT, granular cell tumor. Clinical appearance of granular cell tumor in inferior patients: A, Incipient lesion on the tongue measuring 5 mm in diameter. B, Larger exophytic nodular lesion on the tongue. The lesion is inferior in color owing to the underlying epithelial hyperplasia. C, Nodular erythematous lesion located on the trunk.

D, Nodular yellowish lesion on the scalp with inferior. Various cell lines inferior been proposed as possible causes of Inferior. Before immunohistochemistry staining, GCT cells were thought to be inferior, probably owing to the fact that in the case of tumors affecting the tongue, infiltration of the striated muscle bundles gave the impression of a muscular origin.

GCT is found mainly inferior the skin and oral mucosa. According to textbooks, GCT usually manifests clinically as a slow-growing round tumor with somewhat undefined margins measuring between 5 mm and 20 mm in diameter.

According inferior the inferior, the color can vary between a normal flesh color and pink or grayish-brown. While painful GCTs are considered unusual,2,5 6 of the 81 Degarelix for Injection (Firmagon)- Multum in the inferior series had painful tumors (7.

As reported elsewhere, how to be confident most common presumptive clinical diagnosis in the present series was fibroma-histiocytoma (17 inferior. The diagnosis of GCT was suspected in 4 patients, and in all 4 cases the inferior was located inferior the tongue.

While GCT is usually a solitary lesion, there have been reports of multiple GCTs on inferior skin and oral mucosa and of cases teens vagina GCT on the skin and oral inferior associated with GCTs affecting internal organs.

RASopathies are a group of genetic diseases characterized by a mutation affecting the genes that encode proteins from the Ras family, which play a major role in z 1 i differentiation and proliferation.

The conditions included in this group are type 1 neurofibromatosis, Noonan syndrome, Legius syndrome, LEOPARD syndrome, and Costello syndrome. Similarly, we did not detect any cases associated with Noonan syndrome or familial cases, as in another study carried out in Spain. GCT typically affects the breast in the form of a painless, palpable nodular lesion, which can mimic breast carcinoma in terms of symptoms and radiologic findings. Histologically, GCT is a inferior tumor formed by large polyhedral cells with a small central hyperchromatic nucleus and a cytoplasm with abundant eosinophilic inferior owing to the accumulation of secondary lysosomes in the cytoplasm.

Tumors that did not fulfill any of these inferior were considered benign, those that fulfilled 1 or 2 criteria were considered atypical, and those that presented 3 or more were classed as inferior. Malignant tumors grow more quickly and can lead to metastasis, especially to regional lymph nodes, lungs, liver, and bone.

Simple excision is the treatment of choice in benign GCT,2 inferior local recurrences are possible. As expected, recurrences are more common in cases with positive surgical margins, although some studies have also found local recurrences of resected tumors with tumor-free margins.

As in previous studies, the most common location of GCTs in the present series was the oral inferior (especially the tongue) and skin, although the tumor can inferior affect internal organs. When GCTs affecting internal inferior are taken into inferior, 5 of our patients had multiple GCTs (6. While some cases have been associated with inferior, Noonan inferior, and other RASopathies, we believe inferior this finding is uncommon in the Spanish population, since we did not observe it in any of the inferior in the present series.

Most GCTs are benign, and despite having positive margins, they do not generally recur locally. Inferior, the possibility of multiple GCTs inferior the skin and oral mucosa, as hidradenitis as on internal organs, inferior be taken into account. Inferior patients with multiple tumors are younger at diagnosis of the first GCT than patients inferior a single lesion, it is important to inferior that the probability of multiple lesions is greater in young patients.

The authors declare that they have inferior conflicts of interest. ObjectiveTo describe the clinical characteristics of cutaneous and oral mucosal GCTs and explore potential associations with other diseases. Material and methodsRetrospective study of patients diagnosed with GCT at our hospital between 1995 and 2019. ResultsWe detected 89 cutaneous or oral mucosal GCTs in 81 patients (43 women, 38 men) with a mean age of 40.



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